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副高级专业技术职务

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孙静

日期:2019年12月12日 编辑:周老师 点击:

1.个人简介(500字,含获奖及学术兼职)

孙静,四川大学副研究员,硕士生导师。2013年博士毕业于四川大学,2014年起在四川大学生物材料工程研究中心工作。主要从事“材料微结构及化学环境设计及其对细胞行为的调控”的相关研究。围绕骨、软骨、神经等组织的结构特点与特殊信号递送特性,结合光掩模技术、微流体芯片、3D打印等先进制造技术,获得模拟骨、软骨、神经等组织微结构与功能的基质材料设计;针对不同细胞对微环境化学和物理空间的需求,获得支持细胞铺展与分化的功能化基质微环境设计;探索基质微环境物理化学信号对细胞行为的调控规律及其分子机制;获得诱导骨、软骨、神经等组织再生的生物材料。近年来,作为负责人主持国家自然科学基金面上项目“双重交联设计的凝胶应力松弛行为调控与干细胞诱导分化”,主持国家自然科学基金青年基金“图案化凝胶微反应器设计调控MSCs/软骨细胞的交互诱导与软骨再生”,作为主研人员参与国家级和部省级项目多项;在国际著名材料类期刊发表第一作者和通讯作者SCI论文10余篇。

2.研究方向

(1)骨/软骨/神经组织修复材料

(2)基于微制造技术的组织仿生构建

(3)功能化基质微环境设计与细胞行为调控

(4)微环境力学信号调控细胞分化的分子机制

3.代表性论文专著(限10篇)(近10年)

(1) Ke Yang,Jing Sun*, Zhenzhen Guo, Jirong Yang, Dan Wei, Yanfei Tan, Likun Guo, Hongrong Luo, Hongsong Fan* and Xingdong Zhang, Methacrylamide-modified collagen hydrogel with improved anti-actin-mediated matrix contraction behavior, Journal of Materials Chemistry B, 2018, 6(45): 7543-7555.

(2) Dan Wei,Jing Sun*, You Yang, Chengheng Wu, Suping Chen, Zhenzhen Guo, Hongsong Fan* and Xingdong Zhang, Cell Alignment Guided by Nano/Micro Oriented Collagen Fibers and the Synergistic Vascularization for Nervous Cell Functional Expression, Materials Today Chemistry, 2018, 8: 85-95.

(3) Dan Wei#,Jing Sun#, Jason Bolderson, Meiling Zhong, Matthew John Dalby, Maggie Cusack, Huabing Yin*, Hongsong Fan*, and Xingdong Zhang, Continuous fabrication and assembly of spatial cell-laden fibers for a tissue-like construct via a photolithographic-based microfluidic chip, ACS Applied Materials Interfaces, 2017, 9(17):14606.

(4)Jing Sun, Dan Wei, Ke Yang, You Yang, Xiaolu Liu, Hongsong Fan* and Xingdong Zhang,The development of cell-initiated degradable hydrogel basing on methacrylated alginate applicable to multiple microfabrication technologies, Journal of Materials Chemistry B, 2017, 5(40): 8060.

(5) Ke Yang#,Jing Sun#, Dan Wei, Lu Yuan, Jirong Yang, Likun Guo, Hongsong Fan* and Xingdong Zhang,Photo-crosslinked mono-component type II collagen hydrogel as a matrix to induce chondrogenic differentiation of bone marrow mesenchymal stem cells, Journal of Materials Chemistry B, 2017, 5(44): 8707-8718.

(6) Xiaolu Liu, Yicong Zuo,Jing Sun*, Zhenzhen Guo, Hongsong Fan* and Xingdong Zhang, Degradation regulated bioactive hydrogel as the bioink with desirable moldability for microfluidic biofabrication, Carbohydrate Polymers, 2017, 178: 8-17.

(7) You Yang#,Jing Sun#, Xiaolu Liu, Zhenzhen Guo, Yunhu He, Dan Wei, Meiling Zhong, Likun Guo, Hongsong Fan* and Xingdong Zhang, Wet-spinning fabrication of shear-patterned alginate hydrogel microfibers and the guidance of cell alignment, Regenerative Biomaterials, 2017, 4(5): 299-307.

(8) Gaocan Li, Ke Yang,Jing Sun* and Yunbing Wang*, Highly specific probe for dual-emissive mitochondrial imaging based on photostable and aqueous-soluble phosphonium fluorophore, Rsc Advances, 2016, 6(96): 94085.

(9)Jing Sun, Dan Wei, Yuda Zhu, Meiling Zhong, Yicong Zuo, Hongsong Fan* and Xingdong Zhang, A spatial patternable macroporous hydrogel with cell-affinity domains to enhance cell spreading and differentiation, Biomaterials, 2014, 35(17): 4759-68.

(10)Jing Sun, Wenqian Xiao, Yajun Tang, Kuifeng Li, Hongsong Fan*, Biomimetic interpenetrating polymer network hydrogels based on methacrylated alginate and collagen for 3D pre-osteoblast spreading and osteogenic differentiation, Soft Matter, 2012, 8(8): 2398-404.

4.联系方式

邮箱地址:jingsun@scu.edu.cn

联系电话:028-85417654

办公地址:生物材料楼3楼附304室