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中级专业技术职务

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金蓉蓉

日期:2019年12月12日 编辑:周老师 点击:

1. 个人简介:

个人经历:

2014.2-至今四川大学生物材料工程研究中心,助理研究员

2008.9-2013.12华东师范大学,生物医学,博士(硕博连读)

2004.9-2008.6兰州大学,生物科学,本科

专注于研究高灵敏度磁共振纳米粒/高分子复合材料的生物安全性评价和临床转化应用。致力于纳米材料调控细胞自噬的生物安全性评价及应用,研究磁性纳米材料诱导免疫细胞的自噬作用及其机制,并利用自噬相关疾病模型探讨纳米材料进行疾病治疗的可能性,促进基础研究向临床应用的转化。在Biomaterials, Cancer Research, ACS Applied Materials & Interfaces, Molecular Cancer Therapeutics等杂志发表SCI论文20余篇,总引用次数为500多次。申请中国专利3项(授权2项)。参与1部生物材料专著的编写。主持并参与多个省部级及国家级科研项目,具有丰富的项目申报和执行经验。

2.研究方向:

1) 诱导自噬的纳米材料的生物安全性研究;

2) 纳米粒子与巨噬细胞的相互作用及相关应用;

3) 基因递送载体的生物学应用研究。

3.代表性论著

1. RongRong Jin, Li Liu, WenCheng Zhu, Danyang Li, Li Yang, Jimei Duan, Zhongyuan Cai, Yu Nie, Yunjiao Zhang, Qiyong Gong, Bin Song, Longping Wen, James M. Anderson, Hua Ai*. Iron Oxide Nanoparticles Promote Macrophage Autophagy and Inflammatory Response through Activation of Toll-like Receptor-4 Signaling. Biomaterials, 2019, 203:23-30.

2. Rongrong Jin,Bingbing Lin, Danyang Li, Hua Ai*, Superparamagnetic iron oxide nanoparticles for MR imaging and therapy: design considerations and clinical applications,Current Opinion in Pharmacology. 2014, 18:18-27.

3. Jimei Duan, Jiuju Du,Rongrong Jin*, Wencheng Zhu, Li Liu, Li Yang, Mengye Li, Qiyong Gong, Bin Song, James M. Anderson, Hua Ai*. Iron oxide nanoparticles promote vascular

endothelial cells survival from oxidative stress by enhancement of autophagy. Regenerative Biomaterials, 2019, 6(4):221-229.

4. Tianying Luo, Hong Liang,Rongrong Jin*, Yu Nie*. Virus inspired and mimetic designs in nonviral gene delivery.The Journal of Gene Medicine. 2019, 21(7): e3090

5. Lizhi Zhang#,Rongrong Jin#, Ran Sun, Lifang Du, Li Liu, Kun Zhang, Hua Ai, Yingkun Guo*. Superparamagnetic Iron Oxide Nanoparticles as Magnetic Resonance Imaging Contrast Agents and Induced Autophagy Response in Endothelial Progenitor Cells. Journal of Biomedical Nanotechnology. 2019,15:396-404.

6. Leqin Xu#, Jian Luo#*,Rongrong Jin#, Zhiying Yue, Peng Sun, Wei Wan, Jishen Zhang, Shichang Li, Mingyao Liu* and Jianru Xiao*. Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption, Mol Cancer Ther, 2016, 15(5):854-65

7. Xiaolong Tang#,Rongrong Jin#, Guojun Qu, Xiu Wang, Zhenxi Li, Zengjin Yuan, Chen Zhao, Stefan Siwko, Tieliu Shi, Ping Wang, Jianru Xiao, Mingyao Liu*, Jian Luo*, GPR116, an Adhesion G-Protein Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway, Cancer Research, 2013, 73(20):6206-6218.

8. QiHong Wu,RongRong Jin, Ting Feng, Li Liu, Li Yang, ChongYang Shen, YuHong Tao, James M. Anderson, Hua Ai*, Hong Li*. Iron Oxide Nanoparticles and Their Induced Autophagy in Human Monocytes. International Journal of Nanomedicine, 2017; 12: 3993-4005.

9. Xiaojun Cai,Rongrong Jin, Jiali Wang, Dong Yue, Qian Jiang, Yao Wu, and Zhongwei Gu*. Bioreducible Fluorinated Peptide Dendrimers Capable of Circumventing Various Physiological Barriers for Highly Efficient and Safe Gene Delivery. ACS Appl Mater Interfaces 2016; 8:5821-5832