个人简介：

      王云兵，博士，教授，国家生物医学材料工程技术研究中心主任、四川大学生物材料工程研究中心主任、中国生物材料学会副理事长、科技部生物材料国际交流合作基地主任、教育部组织再生性生物材料科学与工程创新引智基地主任，“百千万人才工程”国家级人选，“十三五”国家重点研发计划首席、中国心脑血管联盟副理事长、国家有突出贡献中青年专家，国际生物材料科学与工程学会联合会Fellow。

      主要从事用于心脑血管疾病、糖尿病、眼科疾病等治疗的新型生物医用材料和微创植/介入医疗器械的基础研究与产品应用开发。主持开发了一系列国内、国际首创的医疗器械产品并实现大规模临床应用。在此基础上，已申报国内、国际专利300多项，国际期刊发表论文100多篇。

主要研究方向：

一．心脑血管疾病治疗材料及器械研发：

1.心脑血管支架材料及器械前沿研究及产品应用开发

1).支架材料合成、表征、加工及性能研究

2).支架表面抗内膜增生、促内皮再生、抗凝等功能化及仿生涂层构筑

2.经导管微创介入心脏瓣膜前沿研究及产品应用开发

1).动物源瓣膜材料新型交联方式和抗凝、抗钙化新技术研究

2).免疫原位点去除生物瓣膜材料研究

3).新型合成高分子瓣膜材料研究

3.新型抗心衰水凝胶材料研究

4.ECMO系统长效循环抗凝技术研究

5.人工小血管材料研究

6.心血管系统疾病纳米靶向诊疗技术研究

二.基于柔性生物电子材料的智能医疗器械产品研发

三.基于纳米材料和人工智能的各类疾病快速筛查的液体活检技术研究

近年来发表文章：

1.Yang, L., Li, L., Wu, H., Zhang, B., Luo, R., &Wang, Y.(2020). Catechol-mediated and copper-incorporated multilayer coating: An endothelium-mimetic approach for blood-contacting devices.Journal of Controlled Release. 321，59-70

2.Wang, Y., Ma, B., Yin, A., Zhang, B., Luo, R., Pan, J., &Wang, Y.(2020). Polycaprolactone vascular graft with epigallocatechin gallate embedded sandwiched layer-by-layer functionalization for enhanced antithrombogenicity and anti-inflammation.Journal of Controlled Release.320, 226-238

3.Hu, C., Zhang, F., Long, L., Kong, Q., Luo, R.，&Wang, Y.(2020). Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing.Journal of Controlled Release, 324, 204-217

4.Ma, B., Xu, H., Zhuang, W., Wang, Y., Li, G., &Wang, Y.(2020). Reactiveoxygen species responsive theranostic nanoplatform for two-photon aggregation-induced emission imaging and therapy of acute and chronic inflammation,ACS Nano. 14 (5): 5862-5873

5.Liang, Z., Zhang, J., Wu, C., Hu, X., Lu, Y., Wang, G., Yu. F., Zhang. X., &Wang, Y.(2020). Flexible and self-healing electrochemical hydrogel sensor with high efficiency toward glucose monitoring.Biosensors and Bioelectronics, 155:112105

6.Yang, L., Huang, X., Deng, L., Ma, X., Jiang, H., Ning, Q., Liang, Z, Lei, Y., &Wang,Y. (2020). Pre-mounted dry TAVI valve with improved endothelialization potential using REDV-loaded PEGMA hydrogel hybrid pericardium.J. Mater. Chem. B, 8(13), 2689-2701

7.Li,L.,Yang, L., Liao, Y., Yu, H., Liang, Z., Zhang, B., Lan, X., Luo, R., &Wang, Y., (2020). Superhydrophilic versus Normal Polydopamine Coating: A Superior and Robust Platform for Synergistic Antibacterial and Antithrombotic Properties.Chemical Engineering Journal. (in press )

8.Hu, C., Zhang, F., Kong, Q., Lu, Y., Zhang, B., Wu, C.,Luo，R.&Wang, Y.(2019). Synergistic chemical and photodynamic antimicrobial therapy for enhanced wound healing mediated by multifunctional light-responsive nanoparticles.Biomacromolecules.20(12), 4581-4592.

9.Zhang, B., Yao, R., Li, L., Wang, Y., Luo, R., Yang, L., &Wang, Y.(2019). Green Tea Polyphenol Induced Mg2+-rich Multilayer Conversion Coating: Toward Enhanced Corrosion Resistance and Promoted in Situ Endothelialization of AZ31 for Potential Cardiovascular Applications.ACS applied materials & interfaces,11(44), 41165-41177.

10.Lu, Y., Wang, Y., Zhang, J., Hu, X., Yang, Z., Guo, Y., &Wang, Y.(2019). In-situ doping of a conductive hydrogel with low protein absorption and bacterial adhesion for electrical stimulation of chronic wounds.Acta biomaterialia,89, 217-226

11.Jin, L., Guo, G., Jin, W., Lei, Y., &Wang, Y.(2019). Cross-Linking Methacrylated Porcine Pericardium by Radical Polymerization Confers Enhanced Extracellular Matrix Stability, Reduced Calcification, and Mitigated Immune Response to Bioprosthetic Heart Valves.ACS Biomaterials Science & Engineering,5(4), 1822-1832.

12.Lu, J., Zhuang, W., Li, L., Zhang, B., Yang, L., Liu, D., &Wang, Y.(2019). Micelle-Embedded Layer-by-Layer Coating with Catechol and Phenylboronic Acid for Tunable Drug Loading, Sustained Release, Mild Tissue Response, and Selective Cell Fate for Re-endothelialization.ACS applied materials & interfaces,11(10), 10337-10350

13.Guo, G., Jin, W., Jin, L., Chen, L., Lei, Y., &Wang, Y.(2019). Hydrogel hybrid porcine pericardium for the fabrication of a pre-mounted TAVI valve with improved biocompatibility.Journal of Materials Chemistry B,7(9), 1427-1434.

14.Guo, G., Jin, L., Jin, W., Chen, L., Lei, Y., &Wang, Y.(2018). Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response.Acta biomaterialia,82, 44-55.

 

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联系方式

邮箱地址：yunbing.wang@scu.edu.cn

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