1.个人简介

郭立坤，生物医学工程博士，四川大学生物材料工程研究中心副研究员。2003年7月于中国科学院成都有机化学研究所获得理学硕士学位。同年9月考入四川大学生物材料工程研究中心攻读博士学位，2005年3月至2008年4月作为联合培养博士研究生赴日本国家材料研究所（NIMS）进行实验研究，2008年7月获生物医学工程博士学位，毕业后留四川大学生物材料中心工作至今。本人一直从事生物医用材料研究工作，主持国家自然科学基金、四川省科技厅支撑计划项目、广西省科技厅重点研发计划项目、广西省科技厅科学研究与技术开发计划项目等科研项目；参与国家重点研发计划、国家重点基础规划发展项目“973”计划、国家高技术研究发展项目863重大计划、国家自然科学基金重大项目、重点项目等国家和部省级重点项目的研究工作；正在承担国家重点研发计划子课题研究工作。

2.研究方向

1、软骨诱导性支架的设计、制备及应用

2、骨诱导性3D打印陶瓷植入体的研制

3、支架材料微环境的调控及其对细胞行为的影响

3.代表性论文专著

1. Likun Guo, Yujiang Fan, Naoki Kawazoe, Hongsong Fan, Xingdong Zhang*and Guoping Chen*. Fabrication of gelatin-micropatterned surface and its effect on osteogenic differentiation of hMSCs. J. Mater. Chem. B, 2018,6, 1018-1025.

2. Yilu Ni, Zhurong Tang, Jirong Yang, Yongli Gao, Hai Lin*,Likun Guo*,Kai Zhang and Xingdong Zhang. Collagen structure regulates MSCs behavior by MMPs involved cell–matrix interactions.J. Mater. Chem. B, 2018,6, 312-326.

3. Yongli Gao,Bao Li, Weili Kong, Yilu Ni,Likun Guo*, Hai Lin, Hongsong Fan, Yujiang Fan, Xingdong Zhang. Fabrication and characterization of collagen-based injectable andself-crosslinkable hydrogels for cell encapsulation. Colloids and Surfaces B: Biointerfaces 2018,167,448–456

4. Yongli Gao, Bao Li, Lu Yuan,Likun Guo*, Chuan Li, Hongsong Fan, Yujiang Fan, Xingdong Zhang.Injectable and self-crosslinkable hydrogels based on collagen type II and activated chondroitin sulfate for cell delivery. International Journal of Biological Macromolecules 2018, (118): 2014-2020

5. Bao Li, Yongli Gao,Likun Guo*, Yujiang Fan, Naoki Kawazoe, Hongsong Fan, Xingdong Zhang, Guoping Chen. Synthesis of photo-reactive poly(vinyl alcohol) and construction of scaffold-free cartilage like pellets in vitro. Regenerative Biomaterials 2018, 159–166

6. Yongli Gao^#; Kuifeng^#;Likun Guo*, Hongsong Fan; Yujiang Fan; Xingdong Zhang. Fabrication of biomimetic hydrogel for chondrocyte delivery. Materials Letters 2020, 126660

7. Lu Yuan, Bao Li, Jirong Yang, Yilu Ni, Yingying Teng,Likun Guo*, Hongsong Fan, Yujiang Fan, and Xingdong Zhang*. Effects of Composition and Mechanical Property of Injectable Collagen I/II Composite Hydrogels on Chondrocyte Behaviors. Tissue Engineering: Part A 2016, 22 (11) 899-906.

8. Yilu Ni, Zhurong Tang, Wanxu Cao, Hai Lin, Yujian，Likun Guo*, Xingdong Zhang*. Tough and elastic hydrogel of hyaluronic acid and chondroitin sulfate as potential cell scaffold materials.Int J Biol Macromol，2014，（74C）：367-375

9. Yang, Xiaoqin，Guo, Likun，Fan, Yujiang，Zhang, Xingdong, Preparation and characterization of macromolecule cross-linked collagen hydrogels for chondrocyte delivery,International Journal of Biological Macromolecules,2013,61：487-493

10. Li Zhang, Tun Yuan,Likun Guo, Xingdong Zhang，An in vitro study of collagen hydrogel to induce the chondrogenic differentiation of mesenchymal stem cells，Journal of Biomedical Materials Research Part A,2012,100A（10）：2717-2725

4.联系方式

邮箱地址：likunguo@scu.edu.cn

联系电话：028-85415123

办公地址： 生物材料楼710室