个人介绍
杨晓，2013年博士毕业于新加坡国立大学生物医学工程系，生物力学专业，加入张兴栋院士课题组。至今主持和参与了国家级项目等8项，发表论文26篇，参编外文专著2部。主要工作内容有：（1）参与本团队“人体硬组织生物活性材料与宿主的相互作用”基金重大项目，研究并证实钠钾泵在磷酸钙陶瓷骨诱导过程中的作用（青年基金，主持）；（2）系统开展了以防治骨质疏松为目标的不同剂型的陶瓷骨修复材料研究（面上项目及四川省科技计划项目，主持），近五年内以第一或通讯作者在《Biomaterials》《Nanoscale》等国际著名生物材料期刊上发表骨质疏松防治相关论文9篇，获中国韩国生物材料学会联合颁发的第一届青年科学家奖；（3）作为子课题负责人承担国家“十三五”项目，研究了钙磷纳米粒子对肿瘤细胞的选择性凋亡作用，参与生物材料基因组数据库的开发和建设,与华西骨科和本团队共同研发出肿瘤术后骨再生修复材料，相关成果于2019年在science子刊《Science Advances》上发表（并列通讯作者），入选中国科协青年人才托举工程。
协助指导5名硕士研究生，2名博士研究生。其中4人于中国生物材料大会获口头报告奖；2人于世界生物材料大会、世界陶瓷大会口头报告；1人蓝光集团一等奖学金；1人光华奖学金。
研究方向
1.生物力学，纳米力学，粘弹性；显微CT影像及建模。
2.骨质疏松/骨肿瘤细胞、动物模型及治疗方案的生物学评价；
3.材料与细胞互作信号通路，材料的组织诱导机理。
代表性论文专著（限10篇）（近10年）：
Kun Zhang, Yong Zhou, Cong Xiao, Wanlu Zhao, Hongfeng Wu, Jiaoqing Tang, Zhongtao Li, Sen Yu, Xiangfeng Li, Li Min, Zhentao Yu, Gang Wang, Lin Wang, Kai Zhang,Xiao Yang*,Xiangdong Zhu*, Chongqi Tu*, Xingdong Zhang, Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect,Science Advances, 2019, 02 Aug
Rui Zhao, Siyu Chen, Bo Yuan, Xuening Chen, Xi Yang, Yueming Song, Hai Tang,Xiao Yang*, Xiangdong Zhu*, Xingdong Zhang, Healing of osteoporotic bone defects by micro-/nano-structured calcium phosphate bioceramics,Nanoscale, 2019(11): 2721-2732.
Yu Zhu, Kun Zhang, Rui Zhao, Xingjiang Ye, Xuening Chen, Zhanwen Xiao,Xiao Yang*, Xiangdong Zhu*, Kai Zhang, Yujiang Fan, Xingdong Zhang, Bone regeneration with micro/nano hybrid-structured biphasic calcium phosphate bioceramics at segmental bone defect and the induced immunoregulation of MSCs,Biomaterials, 2017(147): 133-144.
Rui Zhao, Pengfei Xie, Kun Zhang, Zhurong Tang, Xuening Chen, Xiangdong Zhu, Yujiang Fan, Xiao Yang*, Xingdong Zhang*, Selective effect of hydroxyapatite nanoparticles on osteoporotic and healthy bone correlates with intracellular calcium homeostasis regulation, Acta Biomaterialia, 2017(59): 338-350.
Bo yuan, Maria Grazia Raucci*, Yujiang Fan, Xiangdong Zhu,Xiao Yang*, Xingdong Zhang, Matteo Santin, Luigi Ambrosio, Injectable strontium-doped hydroxyapatite integrated with phosphoserine-tethered poly(epsilon-lysine) dendrons for osteoporotic bone defect repair, Journal of Materials Chemistry B, 2018(6): 7974-7984.
Zhurong Tang, Yanfei Tan, Yilu Ni, Jing Wang, Xiangdong Zhu, Yujiang Fan, Xuening Chen,Xiao Yang*, Xingdong Zhang*, Comparison of ectopic bone formation process induced by four calcium phosphate ceramics in mice, Material Science and Engineering C, 2017(70): 1000-1010.
Siping Xiong1,Xiao Yang1, Xiaofei Yan, Fei Hua, Mengyuan Zhu, Lei Guo, Zhiyuan Wu, Jin-song Bian, Immunization with Na+/K+ ATPase DR peptide prevents bone loss in an ovariectomized rat osteoporosis model, Biochemical Pharmacology, 2018, https://doi.org/10.1016/j.bcp.2018.08.024.
Kun Zhang, Jieyu Zhang, Kelei Chen, Xuefeng Hu, Yunbing Wang,Xiao Yang*, Xingdong Zhang, Yujiang Fan, In vitro and in vivo assessment of nanostructured porous biphasic calcium phosphate ceramics for promoting osteogenesis in an osteoporotic environment, RSC advances, 2018(8): 14646-14653.
Xuelei Zhang, Zhurong Tang, Yong Zhou, Xuening Chen, Xiandong Zhu, Yujiang Fan, Yu Zhang,Xiao Yang*, Chong-qi Tu, Xingdong Zhang, A multi-level comparative analysis of human femoral cortical bone quality in healthy cadavers and surgical safe margin of osteosarcoma patients, Journal of the Mechanical Behavior of Biomedical Materials, 2017 (66) 111-118.
Fangzhu Qing, Pengfei Xie, Yacincha Selushia Liem, Xuening Chen, Xiangdong Zhu, Yujiang Fan,Xiao Yang*, Xingdong Zhang, Administration duration influences the effects of low-magnitude, high-frequency vibration on ovariectomized rat bone,Journal of Orthopaedic Research, 2016(34): 1147-1157.
联系方式
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联系电话：028-85417654
