1. 个人简介
2005-2009年于四川大学化学学院学习获理学学士学位，2009-2014年于四川大学生物材料工程研究中心学习获高分子化学与物理专业理学博士学位，导师为顾忠伟教授，研究方向为基于肽类树状大分子及星形聚多肽的纳米杂化材料作为药物载体用于抗癌药物的传递和癌症治疗。2014-2016年在新加坡南洋理工大学（NTU）化学与生物医学工程学院（SCBE）做博士后，合作导师为Mary Bee Eng, Chan-Park,研究方向为抗菌高分子的设计、合成及其抗菌性能评价。2017年7月入职四川大学生物材料中心，任特聘副研究员，主要研究生物医用高分子及其在癌症治疗、医疗器械、抗菌等生物医学领域的应用。负责国家自然科学基金青年项目、四川省应用基础面上项目及四川大学引进人才启动基金各1项，参研国家重点研发计划1项，负责并参研多项企业技术开发项目，申请中国专利多项其中两项已获得授权。以通讯/第一作者身份共发表SCI文章多篇，相关成果发表于Biomaterials，Chem. Commun.，Biomacromolecules, J. Mater. Chem. B, Polym. Chem., Biomacromol. Biosci.等刊物。
2. 研究方向
1.抗肿瘤高分子基纳米药物；
2.高分子医疗器械；
3.抗菌肽与抗菌高分子。
3.代表性论文专著（限10篇）（近10年）
1.Qingqing Pan, Boya Zhang, Xinyu Peng, Shiyu Wan, Kui Luo, Wenxia Gao,Yuji Pu*, and Bin He. A Dithiocarbamate-Based H2o2-Responsive Prodrug for Combinational Chemotherapy and Oxidative Stress Amplification Therapy.Chemical communications2019,55, 13896-13899.
2.Furong Cheng, Ting Su,Yuji Pu*, Wenxia Gao, Bin He. Polymer Structure-Guided Self-Assisted Preparation of Poly(ester-thioether)-Based Hollow Porous Microspheres and Hierarchically Interconnected Microcages for Drug Release.Macromolecular Bioscience2019,DOI:10.1002/mabi.201900171.
3.Xinyu Peng, Qingqing Pan, Boya Zhang, Shiyu Wan, Sai Li, Kui Luo,Yuji Pu*, Bin He. Highly stable, coordinated polymeric nanoparticles loading copper (II) diethyldithiocarbamate for combinational chemo/chemodynamic therapy of cancer.Biomacromolecules2019, 20, 2372-2383.
4.Furong Cheng, Ting Su, Kui Luo,Yuji Pu*, Bin He, The polymerization kinetics, oxidation-responsiveness, and in vitro anticancer efficacy of poly(ester-thioether)s.Journal of Materials Chemistry B2019, 7, 1005-1016.
5.Junhua Li, Xuequan Zhang, Mingying Zhao, Lihuang Wu, Kui Luo,Yuji Pu*, Bin He. Tumor-pH-Sensitive PLLA-Based Microsphere with Acid Cleavable Acetal Bonds on the Backbone for Efficient Localized Chemotherapy.Biomacromolecules2018, 19, 3140-3148.
6.Ting Su, Furong Cheng, Jianqin Yan, Jun Cao, Kui Luo,Yuji Pu*, Bin He. Hierarchical nanocomposites of graphene oxide and PEGylated protoporphyrin as carriers to load doxorubicin hydrochloride for trimodal synergistic therapy.Journal of Materials Chemistry B2018, 6, 4687-4696.
7.Long Xu, Yidi Yang, Mingying Zhao, Wenxia Gao*, Hai Zhang, Sai Li, Bin He,Yuji Pu*. A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability,Journal of Materials Chemistry B2018, 6, 1076-1084.
8.Long Xu, Mingying Zhao, Yidi Yang, Yan Liang, Changzhen Sun, Wenxia Gao*, Sai Li, Bin He,Yuji Pu*. A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy.Journal of Materials Chemistry B2017,5, 9157-9164.
9.Yuji Pu,Zheng Hou, Mya Mya Khin, Rubi Zamudio-Vazquez, Kar Lai Poon, Hongwei Duan, and Mary B. Chan-Park*. Synthesis and antibacterial study of Sulfobetaine/Quaternary ammonium-modified star-shaped Poly[2-(dimethylamino)ethyl methacrylate]-based copolymers with an Inorganic Core.Biomacromolecules2017,18(1), 44-55.
10.Yuji Pu, Shuang Chang, Hui Yuan, Gang Wang, Bin He*, Zhongwei Gu*. The anti-tumor efficiency of poly (L-glutamic acid) dendrimers with polyhedral oligomeric silsesquioxane cores.Biomaterials2013;34:3658-66.
4.联系方式
邮箱地址：yjpu@scu.edu.cn
联系电话：028-85412923
办公地址： 四川大学望江校区生物材料楼707室
