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副高级专业技术职务

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李高参

日期:2019年12月12日 编辑:周老师 点击:

职称职务:副研究员

专业:生物医学工程

电话:13540813678

电子邮箱:gaocanli@scu.edu.cn

个人简历:

2017.10-至今 四川大学,生物材料工程研究中心,副研究员

2014.05-2017.10 四川大学,生物材料工程研究中心,助理研究员

2008.09-2013.07 四川大学,化学学院,理学博士

2003.09-2007.07 四川大学,化学学院,理学学士

主要工作业绩:

主要从事新型交联剂的开发并用于功能化人工心脏瓣膜的研究,目前已研发出系列具有优异生物相容性的噁唑烷类交联剂。并在此基础上,成功获得了系列具有抗凝血、抗钙化性能以及促细胞粘附等功能的人工心脏瓣膜材料。近年来,在Adv. Funct. Mater.、Angew. Chem. Int. Ed.、ACS Appl. Mater. Interfaces和Nano Res.等国际权威刊物发表论文20余篇。

主要研究方向:

1. 噁唑烷类新型功能化交联剂的开发

2. 新型功能化人工心脏瓣膜材料的开发

3. 新型可预装人工心脏瓣膜材料的开发

主要在研项目:

1. 四川省重大科技专项(2018SZDZX0011),项目负责人

2. 国家自然科学基金青年基金(21502129),项目负责人

3. 四川大学青年科研启动基金(2015SCU11039),项目负责人

4. 国家重点研发计划(2016YFC1102201),分课题负责人

5. “863”项目(2015AA034202),课题骨干

近期研究成果:

1. Boxuan Ma, Weihua Zhuang, Haiyang He, Xin Su, Tao Yu, Jun Hu, Li Yang,*Gaocan Li,* and Yunbing Wang, Two-photon AIE probe conjugated theranostic nanoparticles for tumor bioimaging and pH-sensitive drug delivery, Nano Res. 2019, 12, 1703.

2. Weihua Zhuang, Li Yang, Boxuan Ma, Qunshou Kong,Gaocan Li,* Yunbing Wang,* and Ben Zhong Tang, ACS Appl. Mater. Interfaces 2019, 11, 20715.

3. Jun Hu, Weihua Zhuang, BoXuan Ma, Xin Su, Li Yang,*Gaocan Li* and Yunbing Wang, A two-photon fluorophore labeled multi-functional drug carrier for targeting cancer therapy, inflammation restraint and AIE active bioimaging. J. Mater. Chem. B, 2019, 7, 3894.

4. Weihua Zhuang, Yangyang Xu,Gaocan Li,* Jun Hu, Boxuan Ma, Tao Yu, Xin Su, and Yunbing Wang*, Redox and pH Dual-Responsive Polymeric Micelles with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy, ACS Appl. Mater. Interfaces 2018, 10, 18489.

5. Gaocan Li,* Yangyang Xu, Qunshou Kong, Weihua Zhuang and Yunbing Wang,* Cation–anion interaction directed dual-mode switchable mechanochromic luminescence, J. Mater. Chem. C, 2017, 5, 8527.

6. Weihua Zhuang, Boxuan Ma,Gaocan Li,* Gongyan Liu and Yunbing Wang*, Redox-Sensitive Polymeric Micelles Based on Tetraphenylethylene-Conjugated Copolymer for Aggregation-Induced Emission Active Imaging and Drug Delivery, J. Biomed. Nanotechnol. 2017, 13, 1480.

7. Gaocan Li, Shiyong Zhang, Ningjie Wu, Yangyang Cheng, and Jingsong You, Spontaneous Counterion-Induced Vesicle Formation: Multivalent Binding to Europium(III) for a Wide-Range Optical pH Sensor, Adv. Funct. Mater. 2014, 24, 6204.

8. Gaocan Li, Feijie Song, Di Wu, Jingbo Lan, Xingyan Liu, Jie Wu, Shuaijun Yang, Dan Xiao, and Jingsong You, Cation–Anion Interaction-Directed Molecular Design Strategy for Mechanochromic Luminescence, Adv. Funct. Mater. 2014, 24, 747.

9. Gaocan Li, Shengyou Qian, Chunxia Wang, and Jingsong You, Palladium(II)-Catalyzed Dehydrogenative Cross-Coupling between Two Csp3-H Bonds: Unexpected C=C Bond Formation, Angew. Chem. Int. Ed. 2013, 52, 7837.